sultiame 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2540	61-56-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulthiame
sulphenyltame
sulphenytame
sulphthiame
sulthiam
sulthiamine
sultiame
sultiam
trolone

Molecular weight: 290.35
Formula: C10H14N2O4S2
CLOGP: 0.03
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 97.54
ALOGS: -2.17
ROTB: 2

Drug dosage:

Dose	Unit	Route
0.40	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital cyst	142.05	81.79	14	451	14	63488543

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital cyst	81.68	75.78	8	536	8	79743836

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital cyst	21.82	19.85	3	10	3	89776

Pharmacologic Action:

Source	Code	Description
ATC	N03AX03	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.0	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	8.05		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	6.43		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	7.37		CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	6.87		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	7.19		CHEMBL
Carbonic anhydrase	Enzyme		CAN_YEAST		Ki	5.99		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	8.05		CHEMBL
Alpha carbonic anhydrase	Enzyme		B5SU02_9CNID		Ki	7.34		CHEMBL
Carbonic anhydrase	Enzyme		C0IX24_9CNID		Ki	6.91		CHEMBL
Astrosclerin-3	Enzyme		A6YCJ1_9METZ		Ki	6.56		CHEMBL
Beta-carbonic anhydrase 1	Enzyme		MTCA1_MYCTU		Ki	5.29		CHEMBL
Delta carbonic anhydrase	Unclassified		Q5U9J1_THAWE		Ki	6.77		CHEMBL
Carbonic anhydrase 2	Enzyme		MTCA2_MYCTU		Ki	6.18		CHEMBL
Carbonic anhydrase	Enzyme		Q5TU56_ANOGA		Ki	6.58		CHEMBL
Carbonic anhydrase, alpha family	Unclassified		Q31FD6_HYDCU		Ki	6.37		CHEMBL
Carbonate dehydratase	Enzyme		B2V8E3_SULSY		Ki	8.11		CHEMBL

External reference:

ID	Source
D01787	KEGG_DRUG
CHEBI:32171	CHEBI
OSP	PDB_CHEM_ID
CHEMBL328560	ChEMBL_ID
C084593	MESH_SUPPLEMENTAL_RECORD_UI
DB08329	DRUGBANK_ID
10240	RXNORM
007045	NDDF
420672000	SNOMEDCT_US
50580004	SNOMEDCT_US
C0038807	UMLSCUI
1434	INN_ID
5356	PUBCHEM_CID
I00Q766CZ2	UNII

Pharmaceutical products:

None